For many women, the days leading up to their period can be fraught with unwelcome physical and psychological symptoms. Fluid retention, mood changes, weight gain, breast tenderness and swelling -- these are just a few of the unpleasant features that can be associated with the menstrual cycle. Premenstrual Syndrome (PMS) is so prevalent in women that research shows around 90 percent of women experience at least one symptom of PMS every month and around 50 percent of women identify with having several symptoms. However, a significant number of menstruating women, between five to eight percent, experience much more severe symptoms during this time -- a condition that is now recognised as Premenstrual Dysphoric Disorder, also known as PMDD. The psychological symptoms of the disorder can be so debilitating that PMDD was recognised as a depressive disorder in the fifth edition of the Diagnostic And Statistical Manual of Mood Disorders (DSM-5), published by the American Psychiatric Association in 2013."I see often the worst cases. It's not unusual for a woman [with PMDD] to come in with a partner, to sit down and start weeping, and say 'I want everything out. Many women find it's difficult, if not impossible, to work. I want my uterus, tubes and ovaries out.'" Director of the WHRIA and Associate Professor of Reproductive Endocrinology at UNSW John Eden told Huff Post Australia."That's often the opening line, that's how desperate they are. It's really, really destructive."So what exactly is PMDD? buy dapoxetine in thailand In every pregnancy, a woman starts out with a 3-5% chance of having a baby with a birth defect. 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