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O 0 Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug-induced edema or edema secondary to heart failure Adults: Initially, 250 to 375 mg P. Paresthesias, GI disturbances, and lethargy are common. As your body adjusts to the medicine during treatment these side effects may go away. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. A heterocyclic sulphonamide used to manage respiratory acidosis by inhibiting renal carbonic anhydrase, which increases renal excretion of Na , K , and bicarbonate, and reduces ammonia excretion. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. This material does not endorse drugs, diagnose patients, or recommend therapy. in divided doses q 6 to 8 hours, or 5 to 10 mg/kg I. q 6 hours Seizure disorder (given with other anticonvulsants) Adults and children: 250 mg P. daily when given with another anticonvulsant, or 8 to 30 mg/kg daily P. Acetazolamide is also used to reduce fluid retention in congestive heart failure, control secondary glaucoma and preoperatively in acute angle-closure glaucoma, and may be of use in seizures, especially absence seizures. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional: The most common adverse reactions were tiredness, dizziness, depression, shortness of breath, bradycardia, hypotension, diarrhea, pruritus, and rash.[Ref] Very common (10% or more): Heart failure (up to 27.5%), hypotension (systolic blood pressure less than 90 mm Hg) (up to 27.4%), bradycardia (heart rate less than 40 beats per minute) (up to 15.9%), Common (1% to 10%): Cold extremities, arterial insufficiency, palpitation, first degree heart block (P-R interval 0.26 seconds or greater), second or third degree heart block, postural disorders Uncommon (0.1% to 1%): Cardiogenic shock in patients with acute myocardial infarction Rare (0.01% to 0.1%): Disturbances of cardiac conduction, cardiac arrhythmia Very rare (less succinate than 0.01%): Intermittent claudication increased Frequency not reported: Claudication[Ref] Common (1% to 10%): Diarrhea, nausea, dry mouth, gastric pain, constipation, flatulence, heartburn, abdominal pain, vomiting Frequency not reported: Retroperitoneal fibrosis[Ref] Common (1% to 10%): Tiredness, peripheral edema, accident and/or injury, death, fatigue Uncommon (0.1% to 1%): Edema, precordial pain Frequency not reported: Lactic dehydrogenase elevated Postmarketing reports: Chest pain[Ref] Common (1% to 10%): Dizziness, vertigo, stroke, headache Uncommon (0.1% to 1%): Paresthesia, somnolence, impaired concentration Rare (0.01% to 0.1%): Alertness decreased Very rare (less than 0.01%): Amnesia/memory impairment, tinnitus, taste disturbance Frequency not reported: Short-term memory loss Postmarketing reports: Syncope[Ref] Common (1% to 10%): Shortness of breath, wheezing, dyspnea Rare (less than 0.1%): Rhinitis[Ref] Common (1% to 10%): Pruritus, rash Uncommon (0.1% to 1%): Sweating increased Rare (0.01% to 0.1%): Loss of hair Very rare (less than 0.01%): Photosensitivity reactions, psoriasis aggravated, gangrene in patients with preexisting severe peripheral circulatory disorders, hyperhidrosis, alopecia[Ref] Common (1% to 10%): Depression Uncommon (0.1% to 1%): Insomnia, nightmare Rare (0.01% to 0.1%): Nervousness, anxiety Very rare (less than 0.01%): Confusion, hallucination, personality disorder, disturbances of libido Frequency not reported: Sleep disturbance[Ref] Uncommon (0.1% to 1%): Muscle cramps Very rare (less than 0.01%): Arthralgia, arthritis Frequency not reported: Musculoskeletal pain[Ref] Uncommon (0.1% to 1%): Weight gain Frequency not reported: Unstable diabetes Postmarketing reports: Blood triglycerides increased, high density lipoprotein (HDL) decreased[Ref] Rare (less than 0.1%): Visual disturbance, dry and/or irritated eyes, conjunctivitis Frequency not reported: Blurred vision[Ref] Rare (0.01% to 0.1%): Liver function test abnormalities Very rare (less than 0.01%): Hepatitis Frequency not reported: Transaminase elevated, alkaline phosphatase elevated Postmarketing reports: Jaundice, non-specific hepatic dysfunction[Ref] Rare (0.01% to 0.1%): Impotence/sexual dysfunction Very rare (less than 0.01%): Peyronie's disease[Ref] Rare (less than 0.1%): Positive antinuclear antibodies[Ref] Very rare (less than 0.01%): Thrombocytopenia Frequency not reported: Agranulocytosis[Ref] 1. Lopressor (metoprolol)." Novartis Pharmaceuticals, East Hanover, NJ. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. Effect Reduced serum p H; increased urine p H Dazamide®, Diamox® Therapeutics A heterocyclic sulfonamide used to manage respiratory acidosis by inhibiting renal carbonic anhydrase, which ↑ renal excretion of Na , K , and bicarbonate, and ↓ ammonia excretion; acetazolamide is also used to ↓ fluid retention in CHF, control 2º glaucoma and preoperatively in acute angle-closure glaucoma, epilepsy Effect ↓ Serum p H; ↑ urine p H Therapeutic range 10–15 µg/m L Toxic range ≥ 20 µg/m L A drug that inhibits the enzyme carbonic anhydrase in the kidney tubules, thus acting as a diuretic. 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