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    If you are on a personal connection, like at home, you can run an anti-virus scan on your device to make sure it is not infected with malware. If you are at an office or shared network, you can ask the network administrator to run a scan across the network looking for misconfigured or infected devices. Fármaco análogo al sildenafilo, comercializado con el nombre de Viagra, se diferencia de este último en que el efecto del tadalafilo es más prolongado, llegando a ser funcional hasta las 36 horas, mientras que el Sildenafil surte efecto por 4 ó 5 horas. Por este motivo se lo llamó "la píldora del fin de semana". La aprobación del Viagra por la FDA, el 27 de marzo de 1998, fue un innovador evento comercial para el tratamiento de la disfunción eréctil, con ventas que superan los mil millones dólares. Posteriormente, la FDA aprobó Levitra (vardenafilo), el 19 de agosto de 2003, y Cialis (tadalafilo), el 21 de noviembre de 2003. El tadalafilo es descubierto por Glaxo Wellcome (ahora Glaxo Smith Kline) en virtud de una asociación entre Glaxo e ICOS para desarrollar nuevos medicamentos que se inició en agosto de 1991.​ En 1993, el Bothell, Washington, compañía de biotecnología ICOS Corporation comenzó a estudiar el compuesto IC351, un inhibidor de la enzima PDE-5. En 1994, los científicos de Pfizer descubren que el sildefanilo citrato de sildefanil, que también inhibe la PDE5, causó la erección del pene en hombres que participan en un estudio clínico de un medicamento para el corazón. Aunque los científicos de ICOS no hicieron pruebas del compuesto IC351 para el tratamiento de la DE, reconocieron su utilidad potencial para el tratamiento de este trastorno.

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