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    Viagra (sildenafil) and Levitra (vardenafil) are prescription medications used to treat erectile dysfunction and pulmonary arterial hypertension. Viagra was introduced by Pfizer Pharmaceuticals in March 1998 as a treatment for pulmonary arterial hypertension. The clinical trials revealed that the active ingredient — generically known as sildenafil citrate — also relaxed the muscle tissues in the penis, allowing for increased blood flow. Levitra, introduced in 2003 by Bayer Pharmaceuticals and marketed by Glaxo Smith Kline to treat erectile dysfunction, works similarly. In appearance, Viagra tablets are blue, rounded diamonds that are available in 25 mg, 50 mg, and 100 mg doses. Levitra has orange-colored tablets in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. It is recommended that both medications be taken 30 to 60 minutes before sexual activity is intended. Vardenafil was co-marketed by Bayer Pharmaceuticals, Glaxo Smith Kline, and Schering-Plough under the trade name Levitra. As of 2005, the co-promotion rights of GSK on Levitra have been returned to Bayer in many markets outside the U. In Italy, Bayer sells vardenafil as Levitra and GSK sells it as Vivanza. Thus, because of European Union trade rules, parallel imports might result in Vivanza sold next to Levitra in the EU. An orally disintegrating form, marketed as Staxyn and Levitra Soft, has been gaining approvals in countries such as the United States inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.

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