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    The potent Rx creams contain retinoic acid, the active form of vitamin A that immediately binds with receptors on our skin cells, causing them to behave younger and healthier. The question is almost irrelevant (assuming it’s skin-related) because if you’re asking me or any beauty editor with more than five minutes' experience what to do about pretty much any skin issue — acne, fine lines, brown spots, drooping, dullness, dark circles, enlarged pores — retinol will likely be central to the solution. Along with a bunch of other vitamin-A derivatives starting with the letter R, retinol is an example of a retinoid — that’s the catchall term for these A-based formulas, both the over-the-counter (OTC) and prescription varieties. This directive can translate to countless improvements — normalized cell turnover for clear, glowing skin; balanced pigment production for fewer splotches; revved-up collagen synthesis for smoother skin and tighter pores — but it generally comes with an irksome adjustment period. OTC vitamin-A creams, like retinol and retinaldehyde, tend to be weaker because the skin has to convert them to retinoic acid before using them. Speaking from experience, though, that doesn’t mean they can’t take your face off — especially if you’re sensitive. Which is why with any retinoid you have to practice restraint, applying a pea-size drop only one or two nights a week until skin acclimates, and buffering that dose with a squirt of anti-inflammatory serum or lotion (think niacinamide, polyphenols, lipids, ceramides). These are doctors' orders — well-established ones — that I’ve long practiced and preached. According to almost every beauty article I read these days it is just about the only thing that works on wrinkles. There are derivative in cosmetics such as retinal etc but they are not strong enough to be effective I think. What's the reasoning behind bit prescribing it anymore? Trying for a baby at the mo so staying away for the time being but intend to get involved big time once my baby making days are done. You can get A313 on ebay which is similar to Avibon which was v sadly discontinued, you used to be able to buy it over the counter in France. It's a slightly lower concentration than prescription retin a so might be a good place to start United Pharmacies are the online pharmacy. Obagi Nu-Derm uses 0.1% tretinoin (pea sized amount) mixed in the hand at time of application with similar amount of hydroquinone cream. It was found that this combination actually switches on the DNA which produces collagen. (This is what they told me on the Obagi course anyway...).

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