Hydroxychloroquine autophagy inhibitor

Discussion in 'Pharmacy Northwest Canada' started by aveko, 24-Feb-2020.

  1. mrnekto Guest

    Hydroxychloroquine autophagy inhibitor


    Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs that inhibits autophagy, a mechanism associated with its anticancer properties.

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    Hydroxychloroquine Sulfate is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor TLR 7/9. Autophagy inhibition remains a very attractive strategy to augment standard therapy and improve long-term outcomes for a broad range of malignancies. Our collective work, to date, has demonstrated that we are finally on a strategic trajectory to move beyond HCQ with respect to clinical autophagy inhibition. Jun 01, 2018 e21138 Background A potential resistance mechanism to chemotherapy in NSCLC is through activation of cell survival pathways such as autophagy. Studies in genetically engineered mouse models demonstrate that autophagy inhibition suppresses lung tumor development and progression, especially in Kras mutated tumors. We report safety and efficacy of adding an autophagy inhibitor.

    In cancer, authophagy is the process used by cancer cells to “self-eat” in order to survive. Specifically, if authophagy is prolonged this will become a lethal process to cancer. duing chemotheraphy, radiotheraphy, etc.) authophagy is used by cancer cells to survive. However, note that Chloroquine has other properties as well that may be very well related to anti cancer mechanism, such as zinc ionophore, and others (see below the section on mechanisms).

    Hydroxychloroquine autophagy inhibitor

    Targeting Autophagy in Cancer Update on Clinical Trials and., Moving beyond hydroxychloroquine the novel lysosomal.

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  4. Hydroxychloroquine sulfate is a synthetic antimalarial drug which can also inhibit Toll-like receptor 7/9 TLR7/9 signaling. TLR Autophagy Inhibitor inhibitor.

    • Hydroxychloroquine sulfate HCQ sulfate Parasite Inhibitor..
    • Modulation of autophagy with hydroxychloroquine in patients..
    • Hydroxychloroquine - Wikipedia.

    May 30, 2017 3545. Background Colorectal cancer CRC cells can become resistant to chemotherapy and anti-angiogenic therapy through autophagy. The antimalarial agent hydroxychloroquine HCQ is a potent inhibitor of autophagy, and in vivo studies in CRC cell models show significant decrease tumor volume when these autophagy inhibitors were combined with oxaliplatin and bevacizumab. Hydroxychloroquine HCQ is a lysosomotropic autophagy inhibitor being used in over 50 clinical trials either alone or in combination with chemotherapy. Pharmacokinetic PK and pharmacodynamic PD studies with HCQ have shown that drug exposure in the blood does not correlate with autophagy inhibition in either peripheral blood mononuclear cells or tumor tissue. To better explain this PK/PD. Apr 30, 2019 Anticancer autophagy inhibitors attract ‘resurgent’ interest Despite industry’s past setbacks with autophagy inhibitors, preclinical and clinical findings are starting to revitalize a once.

     
  5. cruz Guest

    Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Chloroquine-Mediated Cell Death in Metastatic Pancreatic. Adjuvant Effect of Chloroquine on Gemcitabine - Full Text. Chloroquine and hydroxychloroquine for cancer therapy
     
  6. Alex Swift Moderator

    Too Little of a Good Thing Hydroxychloroquine in Pregnancy. Women with rheumatic diseases, including inflammatory arthritis and systemic lupus erythematosus SLE, fare better in pregnancy when their disease is under good control1,2. The role of hydroxychloroquine HCQ for achieving this control is now recognized. Several studies demonstrate that patients with SLE who continue HCQ during pregnancy have decreased flares and improved pregnancy outcomes.

    Hydroxychloroquine - Safe In Breastfeeding
     
  7. Florin Well-Known Member

    Pediatric Lupus Different than in Adults MedPage Today Aug 10, 2018 One of the mainstay drugs for pediatric SLE is hydroxychloroquine, with good-quality evidence that antimalarials reduce disease activity and mortality in children. There also is good evidence that hydroxychloroquine helps maintain bone health, helps prevent thrombosis.

    Plaquenil hydroxychloroquine sulfate dosing, indications.