Chloroquine p53 lysosome

Discussion in 'Northwest Pharmacy Canada' started by Veter, 26-Feb-2020.

  1. Avantage Guest

    Chloroquine p53 lysosome


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    Mar 28, 2018 Tumor protein 53 p53 is a transcription factor that regulates genes involved in cell cycle progression, DNA damage response, metabolism, and apoptosis 1,2,3,4of p53 function is often. Tumor protein 53 p53 is a transcription factor that regulates genes involved in cell cycle progression, DNA damage response, metabolism, and apoptosis 1,2,3,4of p53 function is often. Jan 10, 2017 Burikhanov et al. identify the anti-malarial drug chloroquine CQ as a robust secretagogue of tumor suppressor Par-4. CQ-inducible Par-4 secretion is dependent on p53 and Rab8b for vesicle transport. Induction of Par-4 secretion provides an attractive option for the re-purposing of existing drugs for apoptosis and inhibition of tumor metastasis.

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    Chloroquine p53 lysosome

    Chloroquine-Induced Neuronal Cell Death Is p53 and Bcl-2., USP15-dependent lysosomal pathway controls p53-R175H.

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  7. Chloroquine-induced cell death in primary MEFs and human colorectal cancer cells was dependent upon p53, but not upon the p53 modulators Atm or Arf. Accordingly, chloroquine impaired spontaneous lymphoma development in Atm-deficient mice, a mouse model of ataxia telangiectasia, but not in p53-deficient mice.

    • JCI - Targeting lysosomal degradation induces p53-dependent..
    • Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor..
    • Chloroquine activates the p53 pathway and induces..

    Jul 11, 2018 Chloroquine CQ, which is frequently used clinically as an antimalarial agent, is a classic inhibitor of autophagy that blocks the binding of autophagosomes to lysosomes by altering the acidic environment of lysosomes, resulting in the accumulation of a large number of degraded proteins in cells. LC3 assay using chloroquine, an inhibitor of lysosomal acidifi- cation, and the measurement of long-lived protein degradation. Chloroquine treatment led to the accumulation of GFP-LC3 Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

     
  8. Egor Guest

    This is not a list of all drugs or health problems that interact with hydroxychloroquine. Plaquenil, Plaquenil Sulfate, Quineprox hydroxychloroquine. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Conditions that Hydroxychloroquine Oral Treats
     
  9. ProReg XenForo Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine - Side Effects, Dosage, Interactions. Hydroxychloroquine Information for Providers AIDSinfo Hydroxychloroquine Oral Uses, Side Effects, Interactions.
     
  10. diplom15 Well-Known Member

    Hydroxychloroquine An old drug with new relevance. A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula.

    Reducing Risk of Type 2 Diabetes Hydroxychloroquine Use in.