Based on PBPK models results, a loading dose of 400 mg twice daily of hydroxychloroquine sulfate given orally, followed by a maintenance dose of 200 mg given twice daily for 4 days is recommended for SARS-Co V-2 infection, as it reached three times the potency of chloroquine phosphate when given 500 mg twice daily 5 days in advance. It's important to note that the study was examining use of chloroquine and hydroxychloroquine for treatment and prophylaxis of Covid19 infection (anti-viral activity) as well as postulating immuno-modulatory benefits against the 'cytokine storm' which precipitates later ARDS-type respiratory failure. Chloroquine cos-7 24h Hydroxychloroquine causing neuropathy Plaquenil and lymphoma Dermatomyositis hydroxychloroquine rash In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2 – a publication from March 2020 indicating that Hydroxychloroquine was more potent than Chloroquine. The publication further proposes the following treatment schedule. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. That hydroxychloroquine has some antiviral activity in vivo has been reported by two phase II clinical trials.34, 35 The first trial was a small randomised, doubleblind, placebo As a doc with RA, I know that when my hydroxychlorquine dose is upped, I have to take the long view of 3 months when considering if it has helped with inflammation. The immunomodulatory benefits in the short term are not convincing since hydroxychloroquine used in a clinical setting for auto-immune disease is known to be maddeningly slow to show benefit. Is hydroxychloroquine antiviral Is Hydroxychloroquine the Answer to the Coronavirus Pandemic., Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil is taken with or without foodChloroquine method of actionPlaquenil for arthritis pain Safety considerations. The studies reviewed here show that chloroquine/ hydroxychloroquine has in-vitro antiviral effects and anti-inflammatory properties that may be of interest in those viral infections associated with inflammation and/or immune activation. Effects of chloroquine on viral infections an old drug against today's.. Effects of chloroquine on viral infections an old drug.. Hydroxychloroquine Plaquenil thread COVID19. Chloroquine and the 4-aminoquinoline drug hydroxychloroquine belong to the same molecular family. Hydroxychloroquine differs from chloroquine by the presence of a hydroxyl group at the end of the side chain the N-ethyl substituent is β-hydroxylated. This molecule is available for oral administration in the form of hydroxychloroquine sulfate. Hydroxychloroquine, hydroxyurea and didanosine as initial therapy for HIV-infected patients with low viral load safety, efficacy and resistance profile after 144 weeks. Depending on the viral challenging doses and the methods adopted to detect the antiviral effects, the inhibitory concentrations fell within the 05–10 μmol/L range—ie, clinically achievable in plasma during malaria treatment LDT, AS, ID, RC, and AC, unpublished data.