Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil for children Plaquenil and dental work Is plaquenil an nsaid drug What are the side effects of plaquenil Hydroxychloroquine oral tablet is used for short-term treatment of malaria, but it may be used for long-term treatment of lupus or rheumatoid arthritis. Hydroxychloroquine comes with risks if you. Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. Box 1 Main mechanisms of actions by hydroxychloroquine and chloroquine Hydroxychloroquine and chloroquine can inhibit certain cellular functions and molecular pathways involved in immune. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Hydroxychloroquine sulphate mechanism of action Hydroxychloroquine Sulfate Drug Information, Professional, Plaquenil - FDA prescribing information, side effects and uses Hydroxychloroquine dosage for malaria preventionTest done before plaquenilChloroquine phosphate reefHydroxychloroquine manufacturer not workT off plaquenil Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage. Hydroxychloroquine SULFATE -. Mechanisms of action of hydroxychloroquine and chloroquine.. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. TreatmentResearchPharmacologySymptomsRisksInteractionsAdministrationResults Mechanism of action of hydroxychloroquine as an antirheumatic drug. Fox RI1. Author information 1Department of Rheumatology, Scripps Clinic and Research Foundation, La Jolla, CA 92037. The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus. Microbiology –Malaria. Mechanism of action The precise mechanism by which hydroxychloroquine exhibits activity against Plasmodium is not known. Hydroxychloroquine, like chloroquine, is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme.