The recurrent, painful tightening usually occurs in the calf muscles and can cause severe insomnia. The exact mechanism is unknown, but the cramps are probably caused by muscle fatigue and nerve dysfunction rather than electrolyte or other abnormalities. Folic acid and plaquenil Hydroxychloroquine methotrexate drug interactions She started me on the generic version of Plaquenil at 200 mg. I have had a really hard time on this medicine. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these side effects. A week ago I asked if there was anything we could do and she stated that this was t. If you experience stomach upset while taking generic hydroxychloroquine, ask your doctor about trying name-brand Plaquenil instead. While these medications contain the same active ingredient, the preparation of generic hydroxychloroquine can sometimes cause stomach irritation that usually does not occur with the brand name Plaquenil. If you don't mind, could you tell me something? Do most people with RA continue to work full-time? I do, except that I called in sick today because I was up all night with leg cramps, but I'm finding it extremely difficult to stay awake for an eight hour day. I'm 52 and can't retire yet so I'm wondering what people do to make it through the day? Medications that are strongly associated with leg cramps include intravenous iron sucrose, conjugated estrogens, raloxifene, naproxen, and teriparatide. Nocturnal leg cramps are associated with vascular disease, lumbar canal stenosis, cirrhosis, hemodialysis, pregnancy, and other medical conditions. Does plaquenil cause leg cramps Foot and leg cramps Arthritis Information, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Chloroquine resistance in plasmodium vivaxChloroquine sigma solubilityChloroquine parkinsonLow cost hydroxychloroquineIs plaquenil addictive Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Hydroxychloroquine Oral Route Side Effects - Mayo Clinic. Severe Leg Cramps" Rheumatoid Arthritis Community.. Low platelet count thrombocytopenia Causes, treatment.. I started taking Plaquenil 4 weeks ago for non specific autoimmune disease as indicated by ANA. Symptoms were low grade temperature off and on for a year, joint pain and fatigue. I have already felt some relief. Some nauseau at first but less problem with fever and joint pain. But, now I have started having stomach cramps and diarrhea. Hydroxychloroquine Plaquenil is commonly used for treating joint pain in Sjögren’s syndrome patients, based in part on its efficacy in treating the joint pain of patients with systemic lupus erythematosus and rheumatoid arthritis. Consumer information about the medication HYDROXYCHLOROQUINE - ORAL Plaquenil, includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug HYDROXYCHLOROQUINE - ORAL.