I had some of the usual problems with the upset stomach at the beginning but it got better with time. Over the last 8-10 weeks I have noticed that I have been getting very dark circles under my eyes which starts at the inner corner of my eye. What is the maximum dose of plaquenil Plaquenil 200 mg malaria Nail brittleness is a common condition of the elderly. Typically, the cause remains undiscovered, partly because there are so many potential causes. Nail brittleness can result from drugs, a trauma to the nail, or a number of diseases or nutrient deficiencies. When brittle nails split, the name your dermatologist uses may depend on how they split. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Apr 10, 2019 Plaquenil is sometimes given only once per week. Choose the same day each week to take this medicine if you are on a weekly dosing schedule. Take Plaquenil with a meal or a glass of milk. To prevent malaria Start taking Plaquenil 2 weeks before entering an area where malaria is common. Continue taking the medicine regularly during your stay. I thought it was because I was not doing very well for a couple of weeks.... When I looked closer the skin is a little red with a bluish black color like a bruise. Gray nails and plaquenil Hydroxychloroquine Side Effects Common, Severe, Long Term -, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Does plaquenil have small amounts of malaria in itWho makes plaquenil Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Discoloration and Plaquenil - Arthritis Information. Plaquenil Uses, Dosage & Side Effects -. Color of Fingernails and Toenails Health Indicator Chart.. I've been on Plaquenil 400mg a day for almost 4 years. I haven't noticed any skin discoloration but my hair turned grey at a very young age and I've always kept it natural, but as of late it is turning yellowish and my hair dresser thinks it is from the medication. I checked on Mayo Clinic and one of the side effects is hair bleaching. I was diagnosed with Raynauds in 1998. I was told it was severe by a Vascular Surgeon. I don’t have spells, mine is constant my nails are gray and I have modeling on the upper parts on my fingers and my full toes. My skin around my toenails has had ulcers due to the Raynauds. I take Cialis daily to help with blood flow. Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. How common is it?