One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Taking plaquenil with imuran Ocular side effects of hydroxychloroquine Chloroquine alcohol interaction Chloroquine precautions Jan 05, 2020 Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Renal ischemia/reperfusion I/R injury, the major cause of acute kidney injury AKI, is associated with severe morbidity and mortality in both developing and developed countries. Accumulating evidence has suggested that inflammation plays a critical role in the pathology of ischemic injury. Hydroxychloroquine Toxicity Screening Is Key Hydroxychloroquine Plaquenil is a disease-modifying antirheumatic drug that is commonly used to reduce arthritic pain and swelling. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil renal toxicity Drug Toxicity to the Retina and Optic Nerve Are You Missing., Hydroxychloroquine attenuates renal ischemia/reperfusion. Long-term effects of taking plaquenil Feb 19, 2020 Renal clearance in rheumatoid arthritis patients taking PLAQUENIL for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30% and did not correlate with creatinine clearance; therefore, a dosage adjustment is not required for patients with renal impairment. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Drug Toxicity to the Retina and Optic Nerve Are You.. Despite Plaquenil dosing recommendations, retinal toxicity.. Jan 01, 2020 Renal clearance in rheumatoid arthritis RA patients taking Plaquenil for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30%. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. Hypersensitivity to hydroxychloroquine. Caution in patients with previous retinal or visual field changes. SIDE EFFECTS AND ADVERSE REACTIONS. Hydroxychloroquine is generally considered to be the safest DMARD, and a “go to” drug for pregnancy. Retinal pigment changes and retinal toxicity can occur with prolonged use.