It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Chloroquine for giardiasis Other options for hydroxychloroquine plaquenil Plaquenil while pregnant Muscle weakness also may be a side effect of certain drugs used to treat lupus and related conditions, including prednisone and other corticosteroids, cholesterol-lowering drugs and hydroxychloroquine Plaquenil®. Therefore, drug-induced muscle disease should be ruled out as a cause of weakness if you are taking any of these medications, as drug-induced muscle weakness usually does not produce elevated levels of muscle enzymes as is seen in lupus myositis. Muscle weakness and muscle loss death of cells are 2 different issues. Lupus can cause muscles to weaken but disuse atrophy less activity over a long period of time can profoundly weaken muscles. If your muscles are just weakened they can be restrengthened with PT and exercise. I've been taking Plaquenil 400 mg for nearly 6 mos. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Forgot plaquenil muscle weakness Plaquenil weakness - Road Back Foundation, Muscle Weakness? - Human anti-chimeric antibody rituximab hydroxychloroquine Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil and muscle aches and pains? -. Hydroxychloroquine and Colchicine Induced Myopathy The.. Aug 05, 2015 He said in his entire career, he'd never seen a patient have a similar side effect and didn't think it was related to the Plaquenil. He said he would really like me to be on Plaquenil. Muscle weakness is listed as a rare and serious side effect of Plaquenil. Have any of you experienced muscle weakness as a side effect of Plaquenil? Muscle weakness out of the blue is definitely worth mentioning to your doctor. It could be overexertion or something else that needs looking into. That said, I have a lot of weakness in my legs as well. It gets worse when I overdo myself. Heck, I have overall weakness when I overdo myself. Hopefully if you rest as much as you can it'll get better. At the time, she started treatment with Mestinon pyridostigmine and underwent surgical removal of the thymus, or thymectomy, which significantly improved her muscle weakness. About 23 years later, she was diagnosed with lupus and started treatment with Plaquenil hydroxychloroquine to manage joint swelling and tenderness.