While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I was on this hydroxychloroquine for 6 months and then suddenly developed severe itching (burning like sensation, worse than any itch I have ever had) and rash that went from my neck to my feet. Chloroquine for ra Are there withdrawal symptoms from plaquenil Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Its suppose to help with fatigue and joint pain, and has slight blood thinning properties. May be worth looking at what brand you are taking. Some of us get on better with certain suppliers. Dr. Krauser responded Yes. Fatigue is the result of the inflammation. If Plaquenil hydroxychloroquine works, it will also help the fatigue. I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. At first, I was nauseous for a week or so, which the dr. After the nausea went away it seemed like my pain got worse for a week or so, and then it gradually got better. I am also bothered with stomach cramps and mild diarrhea. How does plaquenil help with fatigue Hydroxychloroquine Plaquenil Side Effects & Dosage for., Is extreme fatigue a side effect of Plaquenil - NRAS Plaquenil and taste budsPlaquenil qt prolongation I had pain all over, fatigue and hair loss. Then two months ago I quit taking the Plaquenil, all the Fybromyalgia symptoms went away - much less pain, my hair quit falling out and I feel so much. Hydroxychloroquine Reviews Everyday Health. Plaquenil hydroxychloroquine helps inflammation, will.. Plaquenil and Tiredness - Reviews. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. The Plaquenil sadly didn't reduce or help my fatigue It did help with mouthsores and my rashes although. Fatigue is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years, also take medication Enbrel, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly.