Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Como ayuda el plaquenil es el lupus Plaquenil sun tan Chloroquine agarose gel electrophoresis Inhibits tumor cell growth and metastasis and induces apoptosis in vitro. Binds to FeII-protoporphyrin IX FP to form FP-chloroquine complex resulting in cell lysis and parasite cell autodigestion. Chloroquine CQ and hydroxychloroquine HCQ, two antimalarial drugs, are suggested to have potential anticancer properties. in the present study, we investigated the effects of CQ and HCQ on cell growth of bladder cancer with emphasis on autophagy inhibition and apoptosis induction in vitro. Chloroquine is an antimalarial drug that has been used in humans for many years. In recent years, Chloroquine has been shown to inhibit autophagy and induce apoptosis in malignant cells and thus has been tested in various experimental model systems and in human clinical trials. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine apoptosis Chloroquine activates the p53 pathway and induces., Chloroquine and hydroxychloroquine inhibit bladder cancer. Plaquenil toxicityPlaquenil surgery healingHydroxychloroquine ocular side effectsCan plaquenil cause hearing lossChloroquine and hydroxychloroquine for cancer therapy Chloroquine in combination with radiation inhibited the autophagy induced by radiation and strongly promoted GICs apoptosis. Apoptosis involved many diseases, especially malignant tumors. There are two main apoptotic pathways the extrinsic or death receptor pathway and intrinsic or mitochondrial pathways 20. Chloroquine, an autophagy inhibitor, potentiates the.. Chloroquine Is a Zinc Ionophore - PubMed Central PMC. Chloroquine Modes of action of an undervalued drug.. Targeting apoptosis, angiogenesis and oxidative stress has also been described as efficient tools in augmenting sunitinib anticancer activity. Chloroquine diphosphate, a well-known anti-malarial drug, has been under focus due to its potential cytotoxicity in human cancer cells. Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. References. 1. Induction of Apoptosis by Chloroquine Requires p53. The findings that chloroquine induces apoptosis and activates the p53 pathway raised the question of a causal link between the two phenomena. To address this question, we assessed the effects of p53 knockdown on the efficacy of apoptosis induced by chloroquine.