Chikungunya disease and chloroquine treatment

Discussion in 'Canada Drugs Online' started by Tazio, 12-Mar-2020.

  1. Barko Guest

    Chikungunya disease and chloroquine treatment


    Listing a study does not mean it has been evaluated by the U. Most of cases are expressed as a mild disease, with intense fever and arthralgias, with rare but serious complications (encephalitis, liver, cardiac or renal failures.) having required a hospitalization in an intensive care unit. A severe outbreak of Chikungunya fever has been reported at La Réunion Island (France) in 2005-2006. Chikungunya virus is an alphavirus transmitted to humans by the bite of infected mosquitoes, usually of the genus Aedes (Aedes albopictus in La Réunion).

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    However, a 2018 study looking to use chloroquine against the chikungunya virus found it actually worsened the disease for patients. these cells could be given to health workers on the front lines of treating the disease as a preventive treatment against infection. Chikungunya virus, a re-emerging mosquito-borne alphavirus, causes fever, rash and persistent arthralgia/arthritis in humans. Severe outbreaks have occurred resulting in infections of millions of people in Southeast Asia and Africa. Currently there are no antiviral drugs or vaccines for prevention and treatment of chikungunya infections. A clinical trial conducted during the chikungunya outbreak in 2006 in Réunion Island showed that oral chloroquine treatment did not improve the course of the acute disease De Lamballerie et al. 2008 and that chronic arthralgia on day 300 post-illness was more frequent in treated patients than in the control group Roques et al. 2018.

    Chikungunya was proven in 246 serious cases; 101 patients had comorbidities, and 27% of confirmed cases eventually died. 273 of such serious cases (immediately life threatening condition) have been reported among the cases, in patients aged over 10 days (59% were 65 age old).

    Chikungunya disease and chloroquine treatment

    Chikungunya disease and chloroquine treatment., Approaches to the treatment of disease induced by chikungunya.

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  5. Chikungunya disease and chloroquine treatment. Ilenia Delogu. Unité des Virus Emergents, UMR190 Aix‐Marseille 2 University‐IRD‐EHESP, Marseille, France.

    • Chikungunya disease and chloroquine treatment - Delogu - 2011..
    • Of chloroquine and COVID-19 - ScienceDirect.
    • Treatment of Chikungunya.

    In recent issues, the efficacy of chloroquine and the dosage that may be used in the treatment of acute chikungunya infections was discussed. We have conducted a double-blind placebo-controlled randomized trial on the French Reunion Island Indian Ocean, in which 27 patients received chloroquine and 27 patients received a placebo treatment. The name chikungunya is derived from an African language and means "that which bends up" or "stooped walk" because of the incapacitating joint involvement that may complicate the disease. The treatment and prevention of chikungunya fever are discussed here. The symptoms of chikungunya are similar to those of dengue and Zika, diseases spread by the same mosquitoes that transmit chikungunya. See your healthcare provider if you develop the symptoms described above and have visited an area where chikungunya is found. If you have recently traveled, tell your healthcare provider when and where you traveled.

     
  6. proplakat Guest

    Download PDF Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine (Plaquenil). Plaquenil - FDA prescribing information, side effects and uses Plaquenil hydroxychloroquine – New Warnings Lupus Medicines Hydroxychloroquine - Brigham and Women's.
     
  7. InfoMePlease Well-Known Member

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Plaquenil is used to treat.

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  8. usaoffer Well-Known Member

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted was parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a halflife of about 40 days and a large volume of distribution.

    Hydroxychloroquine MedlinePlus Drug Information