While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I started the hydroxychloroquine medication a week ago and within the first day or two noticed a big difference in my pain and fatigue with major improvement SLE. Plaquenil pulmonary toxicity Hydroxychloroquine sweating Aralen pastillas Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. I have UCTD and Fibromyalgia. My Rheum. has me on prednisone 10 mg and plaquenil 400 mg. I have only been taking the plaquenil for three weeks. Still have alot of fatigue and have been in a mini flare with fever, rash, mouth sores, weakness and joint pains the past few days. 8 replies Plaquenil has beneficial effects on 3 major aspects of lupus; skin rashes, aches & pains and fatigue. It has also been found to help in a number of other features of the disease, though less predictably. It is very effective in the treatment of a whole variety of lupus skin rashes, particularly those found to be worsened by sunlight. I have been getting these horrible rashes and they are not related to sun exposure. I am interested to see if anyone here has gotten a rash from Plaquenil after being on it for several months. Plaquenil for lupus rash Hydroxychloroquine DermNet NZ, Lupus Board Index plaquenil rash Norethindrone and plaquenilChloroquine phosphate 500 mg side effects I have had lupus for 13 years. It took 4 years to diagnose it. My blood tests did not show the normal results for a positive lupus test but the doctor said let's try you on Plaquenil. I responded to the Plaquenil so we decided I have lupus. I was doing fine with no flare ups until last March when I was hospitalized for pain management. Lupus Symptoms and Signs Diagnosis, Treatment, Causes.. Plaqunil rash -. Lupus Medications and Treatments. Plaquenil is also known by its drug name, Hydroxychloroquine. Plaquenil may be prescribed at a low dose for maintenance, or at a high dose to control acute flare-ups. Plaquenil is a disease-modifying drug originally developed to treat malaria. Plaquenil is believed to work by interfering in communication between the cells of the immune system. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Lupus skin rash is the most common complaint among Lupus patients. And the Lupus skin rash treatments that actually work are too few and far in between. Lupus skin rash was once the worst symptom for me. As a woman in her 20’s just diagnosed with lupus, I was desperate to look not only normal but cared a lot about looking good.