Hydroxychloroquine retinopathy cumulative dose

Discussion in 'Aralen' started by Albert Keil, 08-Mar-2020.

  1. iodinlyneed Moderator

    Hydroxychloroquine retinopathy cumulative dose


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    The American Academy of Ophthalmology released an updated set of screening recommendations for hydroxychloroquine Plaquenil and chloroquine to account for the many studies that have shown the effects of these medications on the retina 1. It succinctly makes the case for screening, and CASE REPORT A 61-year-old woman with rheumatoid arthritis treated with 400 mg/kg hydroxychloroquine daily for 6 years daily dose, 5.72 mg/real body weight or 6.5 mg/kg ideal body weight; cumulative dose, 876 g experienced progressive central vision loss and a scotoma affecting her reading ability and was referred to the Retina service. Prior yearly examination with only Ishihara color vision and Amsler grid testing was normal. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily Comments-Each dose should be taken with a meal or a glass of milk.-Retinopathy has been reported to be higher when the maintenance dose is exceeded.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine retinopathy cumulative dose

    Hydroxychloroquine-Induced Retinal Toxicity - American., Case Report Hydroxychloroquine Retinopathy Optometry and.

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  5. An appropriate dose is required to minimize the risk of hydroxychloroquine related retinopathy and to permit long-term use in most patients. The overall risk of developing hydroxychloroquine retinopathy in patients on long-term therapy is 7.5% with the risk increasing with higher doses and long-term use.

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    Pattern of Retinopathy Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. There is an increased risk of HCQ retinopathy with increase in the cumulative dose. Per the prior 2011 AAO guidelines the recommended maximum dose to minimize HCQ retinal toxicity was 6.5 mg /kg based on ideal body weight 2. The advantage of the real body weight formula is that it distributes the risk evenly on a broad range of body habitus. Hydroxychloroquine retinopathy is most influenced by daily dose, length of use, and cumulative dose over time. Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine.

     
  6. inductor Guest

    Hello friends, I take my Plaquenil in the morning with breakfast. Wow now I'm wondering if the meds are what I have been doing wrong !!!! I'm supposed to take 400 morning and same in pm but really I can only handle one dose a day , Wow now I'm wondering if the meds are what I have been doing wrong !!!! I'm supposed to take 400 morning and same in pm but really I can only handle one dose a day , I started out doing it separate too but its just easier to do it in one fell swoop. When best time of day to take plaquenil? - LUPUS UK Plaquenil Tablets - NPS MedicineWise PATIENT FACT SHEET Hydroxychloroquine Plaquenil
     
  7. bimcom XenForo Moderator

    Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. Proven Natural Remedies for Lupus - Healthy Focus Natural Treatments for Lupus Systemic Lupus How is plaquenil hydroxychloroquine used to treat lupus?
     
  8. da User

    PATIENT FACT SHEET Hydroxychloroquine Plaquenil Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid

    Hydroxychloroquine Plaquenil Side Effects & Dosage for.
     
  9. camscomua Guest

    Hydroxychloroquine Oral Uses, Side Effects, Interactions. Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children, dosage.

    Hydroxychloroquine Side Effects, Dosage, Uses, and More