Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine cause low wbc Plaquenil for sinflammatory oa Vitamin b12 deficiency is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Fosamax, and have Osteoporosis Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Annual screening may be commenced before 5 years of treatment if additional risk factors for retinal toxicity exist, such as concomitant tamoxifen therapy, impaired renal function eGFR less than 60 mL/minute/1.73 m 2 or high-dose therapy greater than 5 mg/kg/day of hydroxychloroquine sulfate. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and b12 Plaquenil Side Effects on Your Eyes and Vision, Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Chloroquine treats ovalePlaquenil eye exam how oftenHydroxychloroquine phosphate Vitamin B12 deficiency causes various neuropsychiatric problems ranging from neuropathy to dementia in the elderly. Vitamin B12 deficiency is found to cause neurological and psychiatric problems in adults between 40–90 years of age. It rarely affects people younger than this. Vitamin B12 Deficiency and its Neurological Consequences.. HYDROXYCHLOROQUINE SULFATE Drug BNF content published by NICE. VITAMIN B12 and Neuropathy Mayo Clinic Connect. Hydroxychloroquine may improve symptoms of rheumatoid arthritis symptoms in roughly half a year. If you use this medication and your symptoms don’t improve in that time window, or if they get worse, experts at the National Institutes of Health recommend that you discontinue the medication and call your physician. Vitamin B-12 and Folic acid are B complex vitamins that your body uses to create new cells. They work together with six other B vitamins to aid in growth and repair of your tissues and benefit your overall health and well-being. They are also co-factors in the production and absorption of other vitamins and nutrients. Incidentally, I asked him why plaquenil causes hair loss, and he said no one knows why. It's just one of those drugs known to have that side effect. Nothing to really help it he said, other than taking folic acid, b12 and biotin. I asked him about methotrexate, and he said he was on it for years for his RA and never had any major side effects.