I really don't want to take this or any medication for that matter. So in both of your opinions what did it do for you and/or solve for you that you had going on before you started taking it, I am new here so I hope that question in not too personal or offensive. I have noticed some blurring but I don't think that is from the med. The daily regular pain is still something to deal with though. Having said that I have not seen this medication discussed as being used for Sjorgrens? Since taking the "Plaquenil" the aches and pains throughout my body seem to be much less. As for the eyes, yes you have to get checked regularly. Drug category for hydroxychloroquine Halflife of plaquenil Plaquenil hydroxychloroquine "I am only on Plaquenil a month now for primary Sjogren's Syndrome having been diagnosed in Jan 2014. So far I am feeling much better in that I am sleeping so much better. Before taking medication I would wake 5/6 times a night and found it difficult to go back to sleep now I only wake up once and go back almost immediately. Plaquenil is a drug that has been used to treat malaria for many years. In treating the malaria it was found that the people taking the Plaquenil who also had autoimmune diseases such as rheumatoid arthritis, etc found that their energy level increased, fatigue decreased and their aches and pains decreased. However, measures of salivary and lacrimal gland function did not change during treatment 52. Larger controlled studies of abatacept therapy for primary Sjögren’s syndrome are in progress. Several biologics are under development for the treatment of primary Sjögren’s syndrome that inhibit the activation of T cells. I don’t know why but the hydrochloroquine made that better, I still get it sometimes but not nearly as often or as bad. It isn't fully gone but I am worlds away from where I was. But it could also the pain meds I am on "Tramadol". I am still tired and fall asleep at a moments notice. So that is not much help, the main thing the Plaquenil is supposed to do,( as I understand, feel free to let me know if you know more) it's trying to stop the progression of the disease. Thankfully the incident rate is low for issues but the key is to catch it early, which is why you should go every 6 months. Thank you to everyone for your help and responses!! Is plaquenil used to treat sjogren& 39 Treatment of sicca symptoms with hydroxychloroquine in., What exactly does Plaquenil do. - Sjogren's World Hydroxychloroquine and lansoprazole Sjogren syndrome a disease that causes dryness in the mouth and eyes has been reported by people with rheumatoid arthritis, osteoporosis, multiple sclerosis, high blood pressure, pain. Check the latest reports from 6,549 Sjogren syndrome patients, or browse all conditions. How effective is Plaquenil for Sjogren syndrome by.. Recent advances in primary Sjogren's syndrome. Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment. In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias joint pain, dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” User Reviews for Plaquenil to treat Systemic Lupus Erythematosus The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. I completely agree with Lynnwood that plaquenil helps stop the progression of your disease, so the longer you wait the worse your Sjogren's becomes. Plaquenil is a fairly benign medication and was originally developed to protect against malaria. Later it was found to help autoimmune diseases. It can be months before you get relief with plaquenil.