Chloroquine in cancer therapy a double edged sword of autophagy

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  1. serg62 Well-Known Member

    Chloroquine in cancer therapy a double edged sword of autophagy


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    There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. Autophagy has been found to buffer metabolic stress and may help in cell survival; however, inhibiting autophagy under conditions of nutrient limitation can restore cell death to. It is like a double-edged sword that can play either a protective or destructive role in cancer, by pro-survival. chloroquine, etc. are reported in pre-clinical and clinical study. in cancer therapy. Keywords Autophagy, cancer, ATG, ULK inhibitor, Vps34 inhibitor, mammalian target of rapamycin inhibitors.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Rapamycin and Chloroquine The In Vitro and In Vivo Effects., Autophagy-A double-edged sword in oncology Request PDF

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  7. Jan 01, 2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Kimura T1, Takabatake Y, Takahashi A, Isaka Y. Author information 1Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

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    Sep 01, 2009 The emerging role of autophagy in cancer is one of a double-edged sword Figure 1B. On the one hand, autophagy enables tumor cells to tolerate stress including a hypoxic microenvironment, starvation and probably some forms of therapy. Negative effects of autophagy; Cancer. the lysosomotropic agent chloroquine induces a myopathy in cultured cells and rats similar to that of a human disorder termed distal myopathy with rimmed vacuoles, as well as inclusion body myositis. A Double-Edged Sword. By Takahiro Shintani, Daniel J. Klionsky. Science 990-995. While mounting evidence suggest that autophagy induction enhances immune cell function, autophagy seems to operate as a tumor cells resistance mechanism against immune response. In spite of this, inhibition of autophagy in the clinic can behave as a double-edged sword because it can enhance or suppress cancer immune response.

     
  8. novo28 Guest

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. PLAQUENIL Patient Assistance Program Plaquenil Coupons Save 75% Internet Drug Coupons Plaquenil a possible treatment for Coronovirus.
     
  9. eXtr0gen Guest

    Recruitment of glutathione into the nucleus during cell proliferation. The tripeptide thiol glutathione GSH is at the hub of the complex antioxidant networks of plant and animal cells, participating in cellular redox signalling networks that influence growth, development and defence Foyer and Noctor, 2005; Maughan and Foyer, 2006. Glutathione has long been implicated in the control of growth in animals and plants.

    Polymorphisms of the oxidant enzymes glutathione S.
     
  10. serq Moderator

    Drug Interactions With Hydroxychloroquine Hydroxychloroquine sulfate Plaquenil ® can potentially interact with a few other medications. Some of these medicines that may lead to hydroxychloroquine drug interactions include Certain beta blockers, such as Bisoprolol Zebeta ® Metoprolol Lopressor ®, Toprol XL ® Propranolol Inderal ® Sotalol Betapace ® Timolol Blocadren ®

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