QT prolongation Torsades de pointes Alopecia Anaphylactic reactions Angioedema Cholestasis Dizziness Dyspnea Hepatic failure Hepatitis Hypertriglyceridemia Hypokalemia Increased alkaline phosphatase Increased ALT/AST Jaundice Leukopenia Pallor Seizures Stevens-Johnson syndrome Taste perversion Thrombocytopenia Toxic epidermal necrolysis Hypersensitivity to other azoles Use caution in proarrhythmic conditions and renal impairment Use extreme caution or avoid in congenital long-QT patients and patients with conditions that increase QT-prolongation risk Fluconazole inhibits CYP2C9, CYP2C19, and CYP3A4 isoenzymes; coadministration with drugs that are substrates if these isoenzymes may be contraindicated or warrant dosage modifications Capsules contain lactose and should not be given to patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption Powder for oral suspension contains sucrose and should not be used in patients with hereditary fructose, glucose/galactose malabsorption or sucrase-isomaltase deficiency Syrup contains glycerol; may cause headache, stomach upset, and diarrhea Hepatotoxicity reported with use; use with caution in patients with hepatic impairment Rare exfoliative skin disorders reported; monitor closely if rash develops and discontinue if it progresses When driving vehicles or operating machines, it should be taken into account that dizziness or seizures may occasionally occur Candida krusei is inherently resistant Convenience and efficacy of single dose oral tablet of fluconazole regimen for the treatment of vaginal yeast infections should be weighed against acceptability of higher incidence of drug related adverse events with fluconazole (26%) versus intravaginal agents (16%) If drug is used during pregnancy or if patient becomes pregnant while taking the drug, patient should be informed of potential hazard to fetus; effective contraceptive measures should be considered in women of child-bearing potential who are being treated with 400 to 800 mg/day and should continue throughout the treatment period and for approximately 1 week (5 to 6 half-lives) after the final dose Highly selective inhibitor of fungal cytochrome P-450-dependent enzyme lanosterol 14-alpha-demethylase Subsequent loss of normal sterols correlates with accumulation of 14 alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole Additive: TMP-SMX Y-site: Amphotericin B, amphotericin B cholesteryl sulfate, ampicillin, calcium gluconate, cefotaxime, ceftazidime(? ), ceftriaxone, cefuroxime, chloramphenicol, clindamycin, co-trimoxazole, diazepam, digoxin, erythromycin lactobionate, furosemide, haloperidol, hydroxyzine, imipenem/cilastatin, pentamidine, piperacillin, ticarcillin, TMP-SMX Solution: D5W, LR Additive: Acyclovir, amikacin, amphotericin B, cefazolin, ceftazidime, ciprofloxacin, clindamycin, gentamicin, heparin, meropenem, metronidazole, morphine, piperacillin, potassium chloride, ranitidine with ondansetron, theophylline Y-site: Acyclovir, aldesleukin, allopurinol, amifostine, amikacin, aminophylline, amiodarone, ampicillin-sulbactam, aztreonam, benztropine, bivalirudin, cefazolin, cefepime, cefotetan, cefoxitin, cefpirome, chlorpromazine, cimetidine, cisatracurium, dexamethasone sodium phosphate, dexmedetomidine, diltiazem, diphenhydramine, dobutamine, docetaxel, dopamine, doxorubicin liposomal, droperidol, etoposide PO4, famotidine, fenoldopam, filgrastim, fludarabine, foscarnet, ganciclovir, gatifloxacin, gemcitabine, gentamicin, granisetron, heparin, hetastarch, hydrocortisone, immune globulin, leucovorin, linezolid, lorazepam, melphalan, meperidine, meropenem, metoclopramide, metronidazole, midazolam, morphine, nafcillin, nitroglycerin, ondansetron, oxacillin, paclitaxel, pancuronium, penicillin G, phenytoin, piperacillin-tazobactam, prochlorperazine, promethazine, propofol, quinupristin-dalfopristin, ranitidine, remifentanil, sargramostim, tacrolimus, teniposide, theophylline, thiotepa, ticarcillin-clavulanate, tobramycin, vancomycin, vecuronium, vinorelbine, zidovudine Tablets: Store below 86° F (30° C) Dry powder: Store below 86° F (30° C); reconstituted suspension should be stored between 86° F (30° C) and 41° F (5° C), and unused portion should be discarded after 2 weeks; protect from freezing Injection (glass bottles): Store between 86° F (30° C) and 41° F (5° C); protect from freezing Injection (Viaflex Plus plastic containers): Store between 77° F (25° C) and 41° F (5° C); protect from freezing The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. The discovery of Diflucan (fluconazole) was a major landmark in the pharmaceutical industry, as it was the first antifungal drug to be developed that could be used both orally, for minor infections such as candidiasis, or intravenously for more serious systemic infection like cryptococccal meningitis. Fluconazole development was based on two initial assumptions by the scientists involved: firstly that drugs should be tested in experimental models of infections, and secondly that a polar molecule might have superior pharmacological properties. The developers took these two ideas as a starting point and went through a rigorous process to find the right compound. Eventually they came across 2-(2,4-difluorophenyl)-1,3- (1H-1,2,4-triazol-1-yl)-2-propanol, that is fluconazole. This report details the progressive discovery of fluconazole and all the intermediate steps and compounds found along the way. The report also describes the general development of drugs, the history of antifungal agents of the past and examines the major agents currently available. There is also a section devoted to the clinical and pharmacological profile of fluconazole, and any considerations concerning the future development of antifungal agents.
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care."I have took Diflucan a couple of times in my life, but at the age of 38 I had a surgery to my eye and my doctor had me take diflucan the day before surgery. The next morning I had welts on my face my lips were swollen and they almost cancelled the surgery. I took it again a couple of weeks later and the same thing happened again hearts in the exact same place lip swollen except this time it took longer to go away and I could barely breathe. This sounds like an allergic reaction so I should never take it again.""I have taken Diflucan for yeast infections for years. I always get the infection after having to take antibiotics for a sinus infection (at least 1x/year). Twelve hours after taking the Diflucan, I developed 3 hives- two on my face and one on my thumb. I thought maybe it was from something else or stress, so I ignored it. Had to take a second pill this week, and the hives came back in the exact same places, only worse, and have blistered. Fluconazole fights opportunistic infections in people with HIV. Baxter manufactures the generic version approved in 2000. Fluconazole is used when fungal infections can’t be treated with skin lotions or creams. Antifungals fight infections caused by different kinds of fungus. It is sold under many different names in other parts of the world. It works against several different types of fungus, including the yeast infection called candidiasis or thrush. Many germs live in our bodies or are common in our surroundings. A healthy immune system can fight them off or keep them under control. However, HIV infection can weaken the immune system.
Fluconazole is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, and other organs. Fluconazole is also used to treat meningitis (infection of the membranes covering the brain and spine) caused by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). Fluconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection. Fluconazole comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once a day, with or without food. Generic Name: fluconazole Product Name: Diflucan Diflucan capsules (for adults) and oral suspension (for children) are used to treat certain fungal and yeast infections. Ask your doctor if you have any questions about why Diflucan has been prescribed for you. Your doctor may have prescribed Diflucan for another reason. Diflucan is available only with a doctor’s prescription. Diflucan belongs to a group of medicines called azole antibiotics. It works by preventing the growth of the fungal and yeast organisms causing your infection. Diflucan contains the active ingredient fluconazole: Capsules (50 mg, 100 mg and 200 mg capsules) contain the inactive ingredient gelatin, lactose, maize starch, silicon dioxide, magnesium stearate, sodium lauryl sulfate, titanium dioxide, (50 and 100 mg capsules only), patent blue V. The 100 mg and 200 mg capsules also contain erythrosine; the 200 mg capsules also contain indigo carmine.
Reviews and ratings for diflucan. 106 reviews submitted with a 7.8 average score. The overall incidence of side effects possibly related to DIFLUCAN was 26%. The most common treatment-related adverse events reported in the patients who received 150 mg single dose fluconazole for vaginitis were headache 13%, nausea 7%, and abdominal pain 6%.