Tamoxifen is one of the most common hormonal therapies for hormone-receptor-positive breast cancers (cancerous cells that feed off of certain hormones in the body). It’s usually taken as a pill once a day under the brand name Nolvadex. However, for people who have difficulty taking pills it can be given in a liquid form called Soltamox. Tamoxifen is often administered after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. Sometimes it is started before surgery (as neoadjuvant therapy) as well. Tamoxifen works by blocking/stopping the effects of estrogen in a person’s breast tissue. This is because hormone-receptor-positive breast cancer feeds on hormones (like estrogen or progesterone) to grow. Tamoxifen is a hormonal therapy drug used to treat breast cancer, womb cancer and sometimes other cancers and conditions. It is best to read this information with our general information about hormonal therapies and the type of cancer you have. Like all cancer drugs, tamoxifen can cause side effects. Your cancer doctor, nurse, or pharmacist will tell you how often you will have it. Some of the side effects can be serious, so it is important to read the detailed information below. Your healthcare team can give you advice on how to manage any side effects. Tell your doctor or nurse straight away if you feel unwell or have severe side effects, including any we do not mention here. Your cancer doctor or nurse can explain the risk of these side effects to you. If you need medical attention for any reason other than cancer, always tell the healthcare staff that you are having this treatment. Tamoxifen can be given alone or with other types of treatment.
Tamoxifen, also known by the brand name Nolvadex, is one of the more commonly prescribed medications to prevent breast cancer recurrence, and when used appropriately, may reduce the risk of recurrence (of breast cancer coming back) by roughly 50 percent. The drug may also be used to reduce the chance that a woman will develop breast cancer in the first place, or to slow the growth of metastatic breast cancer. Tamoxifen works by binding to estrogen receptors on breast cells so that estrogen can't bind and stimulate growth. Learn about the potential side effects, how drug interactions may occur, and how tamoxifen differs from aromatase inhibitors. estrogen-like effects, depending on the particular type of tissue in the body where it acts. It is classified as a selective estrogen receptor modulator (SERM) along with the medication Evista (raloxifene). Tamoxifen is usually not considered beneficial for those who have estrogen or progesterone negative breast cancer. However, early detection and good treatments mean that survival rates have increased to about 80% in more developed regions. Animal studies led to the development of tamoxifen, one of the most successful treatments, and more recently Herceptin (trastuzumab) and aromatase inhibitors. The risk of developing breast cancer increases with age, like most cancers. However, there are several factors that affect the likelihood of developing breast cancer. The risk for developing breast cancer approximately doubles if a parent or sibling has been diagnosed with the disease, for example from a 1 in 10 chance to a 1 in 5 chance. This likelihood increases further if there have been several cases in the family or if it has been diagnosed at a young age. A very strong family history can indicate a faulty gene as a major factor.
Tamoxifen is a common medication used to prevent recurrence of breast cancer. Learn about the side effects, risks, drug interactions, and more. Breast cancer treatments are done and I am considered Cancer Free. Post-treatments, women with hormonal cancers usually have to take Tamoxifen and get annual Mammograms!