Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine. All generic medications must undergo certain tests to compare them to brand-name medications. An "AB" rating means that the FDA has determined that a generic medication is equivalent to a brand-name medication. Food and Drug Administration (FDA) then looks at these tests to decide if the generics are equivalent to the brand-name medications and assigns a rating to each one. All of the generic duloxetine versions currently available have an "AB" rating, meaning they should be equivalent to Cymbalta. However, generic medications are allowed to have different inactive ingredients than the brand-name medication. This site does not dispense medical advice or advice of any kind. This might include fillers, dyes, or other ingredients that may cause problems for people with allergies or sensitivities. Indianapolis, IN: Eli Lilly and Company; 2011 March. Site users seeking medical advice about their specific situation should consult with their own physician. Food and Drug Administration, Center for Drug Evaluation and Research. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. Electronic orange book: approved drug products with therapeutic equivalence evaluations. Press "Continue" button below to begin selecting your Health Savvy topic(s). Remember, you need at least one selected topic to use Health Savvy.
A generic version of Cymbalta has been approved by the FDA. However, this does not mean that the product will necessarily be commercially available - possibly because of drug patents and/or drug exclusivity. The following products are equivalent to Cymbalta and have been approved by the FDA: Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Cymbalta. These medications may be counterfeit and potentially unsafe. Patent and Trademark Office at any time during a drug's development and may include a wide range of claims. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. In some cases, they may not be available in all strengths or forms as the brand-name drug. Duloxetine oral capsule is available as the brand-name drugs Cymbalta and Irenka. Generic drugs usually cost less than the brand-name version. Duloxetine oral capsule is used to treat: Duloxetine belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs). It works by balancing chemicals in your brain that cause depression and anxiety. By balancing these chemicals, this drug also helps inhibit pain signals from your nerves to your brain. Duloxetine oral capsule can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You shouldn’t drive, use heavy machinery, or do other dangerous activities until you know how it affects you. In adults, the more common side effects of duloxetine can include: Call your doctor right away if you have serious side effects.
Duloxetine oral capsule is available as both a generic and brand-name drug. Brand names Cymbalta and Irenka. Duloxetine only comes as a capsule you take. Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 20, 30, or 60 mg of duloxetine, respectively.