The overuse of prescription drugs has become a serious problem in the US. Yet what are we taking all these pills for, and are they improving our lives? We hear about this most in the context of opioids — narcotic painkillers whose widespread use and abuse has become a national crisis. The overuse of antibiotics has also become the focus of an intensive campaign to steer doctors and patients to more judicious use. The soaring use of prescription drugs has been driven by several factors: A plethora of new drugs coming to the market; a culture that has come to expect a “pill for every ill”; aggressive marketing to both doctors and consumers by the pharmaceutical industry; and treating some “pre-”diseases with pills rather than with lifestyle changes. Between 19, the number of prescriptions filled in the US increased 85% — from 2.4 billion to 4.5 billion — even though the population increased by just 21%. Nearly half (49%) of adults take at least 1 prescription drug, 23% take 3 or more and about 12% take 5 or more, according to the latest data from the CDC (Centers for Disease Control and Prevention). Orlistat is prescribed to aid weight loss in obese people who have a body mass index (BMI) of 30kg/m² or more. It can also be prescribed to overweight people who have a BMI of 28kg/m² or more, if they have other risk factors for obesity-related diseases, such as type 2 diabetes, high blood pressure or raised cholesterol. Orlistat is not licensed for use in children under 18 years of age. However, it may sometimes be prescribed by specialists for children over 12 years of age who are obese. Orlistat is a type of medicine called a lipase inhibitor. It works by reducing the absorption of fat that you eat. Orlistat is not absorbed into the bloodstream, but works locally in the stomach and small intestine. Here it prevents the action of two enzymes called gastric and pancreatic lipases that are found in the digestive juices.
Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing caloric intake. It is intended for use in conjunction with a healthcare provider-supervised reduced-calorie diet. The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the course of a year. Orlistat also modestly reduces blood pressure and appears to prevent the onset of type 2 diabetes, whether from the weight loss itself or other effects. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do. Benefits aside, however, orlistat is notorious for its gastrointestinal side effects (sometimes referred to as treatment effects), which can include steatorrhea (oily, loose stools). A comprehensive review of the safety and effectiveness of this drug. If the drug is not a Do Not Use product, information on adverse effects, drug interactions and how to use the medication are included.
Common side effects of Xenical include: bowel urgency, frequent bowel movements, oily evacuation, oily rectal leakage, steatorrhea, and flatulence with discharge. See below for a comprehensive list of adverse effects. Applies to orlistat: oral capsule Along with its needed effects, orlistat (the active ingredient contained in Xenical) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking orlistat: Some side effects of orlistat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to orlistat: oral capsule The most commonly reported adverse events have included oily spotting, flatus with discharge, fecal urgency fatty/oily stool, oily evacuation, increased defecation and fecal incontinence. Generic Name: orlistat Product Name: Xenical Xenical is used to treat people who are obese (BMI 30 or higher) or overweight (BMI 27 or higher) with other risk factors (eg high blood pressure, high cholesterol, high blood lipid profile). Your Body Mass Index (BMI) is calculated by dividing your weight (in kg) by your height (in metres) squared. Losing even small amounts of weight and keeping it off produces additional health benefits for you, especially when you are at risk for other diseases such as heart disease and diabetes. Xenical can also help to improve risk factors, such as high blood pressure, high cholesterol, and high blood sugar. If these are not treated, they could lead to other diseases such as hypertension and diabetes. Ask your pharmacist or doctor if you have any questions about obesity-related risk factors. Xenical should be taken in conjunction with a well-balanced calorie-controlled diet and other appropriate measures such as exercise. Xenical belongs to a group of medicines called lipase inhibitors.
They excluded patients who had any clinically significant chronic conditions; had recently. Orlistat in the long-term treatment of obesity in primary care settings. Orlistat is minimally, if at all, absorbed, and its side effects are largely due to its. with more prolonged therapy perhaps due to its adverse effects, leading to a.