Clomid and Cancer IVF1 The available evidence suggests that the risk of developing uterine cancer can be reduced by having a woman take progesterone supplements in addition to estrogen. If she is not ovulating, getting regular ovulation to occur is thought to reduce the risk. Fertility drugs like clomid work by blocking the effects nbsp; Fertility Drugs Seem to Affect Breast Cancer Risk in Younger Women With fertility drugs, as many as eight to 10 mature eggs can be released. But using fertility drugs greatly increases the amount of estrogen in the body. This extra estrogen may stimulate the growth of hormone-receptor-positive breast cancer cells. Still, results from earlier studies on fertility drugs and breast nbsp; Do Fertility Drugs Cause Cancer? What the Research Says PCOS, a common cause of infertility, is also known to come with an increased risk of developing endometrial cancer. Cancer of the cervix is not a type of cancer that is generally regarded as being responsive to hormones. Some studies however suggested that there may be some relationship to the number of deliveries a woman has had. Women with infertility were found in a few studies to have a lower risk for cervical cancer. Women who used clomid, in one study, had an even lower risk for developing cancer. The reasons for this apparent protective effect of clomid are unclear. Uterine cancer, also known as endometrial cancer, is a type of cancer that is influenced by hormones. Use of estrogen has been linked in several studies with the development of uterine cancer.
A study suggests that women younger than 50 who use fertility drugs to successfully conceive a child may have a higher risk of breast cancer. Still, this higher risk is about the same as the average woman’s risk, but higher than women who took fertility drugs and didn’t conceive. The study was published online on July 12, 2012 by the . Read the abstract of “Fertility Drugs and Young-Onset Breast Cancer: Results From the Two Sister Study.”Fertility drugs stimulate the ovaries to produce more mature eggs than normal. Without fertility drugs, only one or two eggs, at most, per cycle are released. With fertility drugs, as many as eight to 10 mature eggs can be released. But using fertility drugs greatly increases the amount of estrogen in the body. This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. News anchor Giuliana Rancic made her breast cancer diagnosis public, there was speculation about whether fertility treatment might have been a factor. To find the most current information, please enter your topic of interest into our search box. On NBC's Today show, Rancic, 37, said she got a mammogram when her doctor strongly recommended it before starting another round of IVF (in vitro fertilization). On their reality TV show, Rancic and her husband, Bill, have chronicled their previous fertility treatments. Rancic's diagnosis has raised questions about whether fertility treatment can increase the risk for breast cancer. Web MD got answers from fertility and breast cancer specialists. Fertility and cancer experts interviewed for this story agree that there is no strong evidence to connect fertility drugs with increased risk for breast cancer. Oncologists add that there is a need for studies that follow women who have undergone IVF for longer periods of time.
Infertility and hormonal fertility treatments may influence the amount of dense tissue in the breast, a risk factor for breast cancer, according to a study involving 43,313 women, published in the open access journal Researchers at Karolinska Institutet, Sweden found that women with a history of infertility had denser breasts than other women. The association was more pronounced in women who had undergone controlled ovarian stimulation (COS), the hormone treatment required for in vitro fertilization. While this may indicate a potential adverse effect of COS on breast density, the researchers point out that the effect may be due to the underlying infertility that motivates the use of a specific treatment, rather than to the treatment itself. Frida Lundberg, lead author of the study, said: "The results from our study indicate that infertile women, especially those who undergo COS, might represent a group with an increased breast cancer risk. While we believe it is important to continue monitoring these women, the observed difference in breast tissue volume is relatively small and has only been linked to a modest increase in breast cancer risk in previous studies." Breast tissue is composed of two types of tissue: dense, fibroglandular and non-dense, fatty tissue. Women with extremely dense breasts have a four to six fold higher risk of developing breast cancer than women with non-dense breasts, previous research has found. In this study, women with a history of infertility were found to have higher absolute dense volume -- that is more dense, fibroglandular breast tissue -- than non-infertile women. However, since that time, more studies have been done, and most have found no significant increase in cancer risk after Clomid use. It is true that a few studies seemed to find a connection between fertility drug use and an increased risk of breast or uterine cancer, specifically with the drug Clomid. In fact, ironically, one study showed that women treated with fertility drugs seemed to show a decreased risk of developing uterine cancer when compared to infertile women who did not seek treatment. Another study found a decreased risk of developing breast cancer after Clomid. The problem with many of these studies is they don't take into account other potential risk factors for uterine cancer. Namely, if a woman never experiences pregnancy, her risk of cancer increases. Also, obesity is not only a risk factor for infertility, but it is also a risk factor for cancer. Instead, the increased incidence may be attributed to the reason behind infertility itself or any number of other factors not taken into account in this study.
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