Apr 30, 2018. It is unclear what causes PMR, and there is currently no cure. Doctors usually prescribe a corticosteroid drug called prednisolone to manage. The initial prednisone dose recommended for polymyalgia rheumatica PMR is 10–20 mg/day. In reality, the doses used generally are closer to 20 mg/day than to 10 mg/day, due to concerns about the risk of treatment failure, said Dr. Luis J. Catoggio, head of rheumatology at the Hospital Italiano de Buenos Aires.