Generic name: Abiraterone acetate Zytiga® is the trade name for the generic drug abiraterone acetate. In some cases, health care professionals may use the generic name abiraterone acetate when referring to the trade name Zytiga®. This medication is classified as an “adrenal inhibitor". (For more detail, see “How Zytiga® Works” below) Zytiga® works by inhibiting specific “enzymes” in your adrenal glands that are responsible for making androgens. For this reason, there is an increased risk of over production of mineralcorticosteroids in your body while on Zytiga®. As a result, Zytiga® may cause hypertension [high blood pressure], hypokalemia [low levels of potassium in the blood], and fluid retention. Because of this risk, Zytiga® should be used cautiously in patients with a strong cardiovascular history, and patients should be monitored closely for these symptoms. Dosing along with prednisone will decrease the risk of mineralocorticoid excess. Side effects that are very rare -- occurring in less than about 10 percent of patients -- are not listed here. Findings from pivotal Phase 3 LATITUDE clinical trial data demonstrated statistically significant and clinically meaningful improvements in patients HORSHAM, PA, Feburary 8, 2018 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U. Food and Drug Administration (FDA) has approved a new indication for ZYTIGA (abiraterone acetate) in combination with prednisone for the treatment of patients with metastatic high-risk castration-sensitive prostate cancer (CSPC). The approval is based on Phase 3 data from the pivotal LATITUDE clinical trial, which found that in patients with metastatic high-risk CSPC, ZYTIGA in combination with prednisone reduced the risk of death by 38 percent compared to placebos. “LATITUDE was a large global trial which produced impressive and clinically significant results in overall survival,” said Karim Fizazi, M. D., Principal Investigator and Head of the Medical Oncology Department at Institute Gustave Roussy, Villejuif, France. “With today’s approval, abiraterone acetate plus prednisone could become a standard of care for patients with metastatic high-risk castration-sensitive prostate cancer.” “Today’s approval marks an important step in addressing the unmet needs of patients with metastatic high-risk castration-sensitive prostate cancer by providing an option that has demonstrated improvement in overall survival,” said Andree Amelsberg, M. D., Vice President of Oncology Medical Affairs at Janssen Biotech, Inc., part of the Janssen Pharmaceutical Companies of Johnson & Johnson. “This milestone is an exciting turning point for researchers and clinicians, and most importantly, for patients suffering from this disease and their families who now have an important additional therapeutic option.” LATITUDE was a multinational, multicenter, randomized, double-blind, placebo-controlled clinical trial that examined the use of ZYTIGA 1,000 mg once daily in combination with prednisone 5 mg once daily, compared to placebos (N=1,199) in patients with newly diagnosed, metastatic high-risk CSPC, who had not received prior cytotoxic chemotherapy. All the patients received a gonadotropin-releasing hormone (Gn RH) analog or had prior bilateral orchiectomy.
It is important that you take it regularly every day. You will also be prescribed another medicine (either prednisone or prednisolone) to take alongside abiraterone. This means taking your dose at least an hour before a mealtime, or waiting for two hours afterwards. In some men with prostate cancer, the cancer cells spread to parts of the body other than the prostate. When this happens, it is referred to as late, advanced or metastatic prostate cancer. Treatment options for this type of cancer typically include hormone treatment, surgery, radiotherapy and chemotherapy. Abiraterone is a hormone treatment - it belongs to a group of medicines known as anti-androgens. I friend of mine experienced the same effects from it. v=dq2u AUjk LIw Age 59 9/8/2011 PSA 4.7 Free PSA 11% 12 Needle Biopsy 9/15/2011 Gleason 3x3, 4 cores involved out of 12 cores within left hemisphere Davinici performed on Jan 3rd 2012Gleason 3x4 Approximately 7% of gland volume (all on left side)Margins: Negative Extraprostatic Extension: Not Observed Pathologic Staging p T2a Regarding insomnia treatment with prednisone, iff you start with Ambien, start with 5 mg and see if that works. I have been on and off of it for many years with no major side effects. I took pills and shots of it directly on the affected nerves. 6: 0.24July 7, 2011: PSA: 0.20Jan 5, 2013: PSA: 0.25 Todd - I've used the benadril in the past and it was helpful, but with the Prednisone - on day 2 it did not seem to do anything. Where things are as of Day Seven on the Prednisone. My plan was just to keep the to-do list but not actually do anything other than what I wanted (Thats a retired thing ). I started Abiraterone (zytiga) this last week - actually this is my third day. Short term use is not habit forming and usually is well tolerated. I took it for a several weeks and built up a huge residual in my system to the point I was missing turns I should have taken and such. I did sleep good and it seems to have a tolerable hang over effect if not taken every night like I was. I still have a bigger appetite but it is not nearly as a acute as it was. Age 52; dx at 50, PSA 54.9Nerve sparing surgery/open, 2010; removed 14 lymph nodes Pathology report: T3b N0MX, SVI, neg margin, Gleason 9HT: Lupron bicalutamide, up to 36 months: 15 months so far Finished Adjuvant RT incl lymph nodes, 9/2011Starting adjuvant Taxotere Latest PSA I was on it for months when my back went out. As my bride has diabetes dx'ed late last year - we have to be careful on portions for her during meals, its easier if I eat the same portions as she does. When I wake up around 3 AM I have to eat something. I have this around the house to-do list I've been keeping - have actually started doing things on the to-do list! If you have continued insomnia, consider having your physician write you a prescription for Ambien. I've taken to snacking on pretzels during the day, as in just about all day - thats in addition to the three meals a day. One in the morning (with food) and one with dinner. Around 830 PM or so I seem to run out of steam, around 10 PM Wired! The first night I think I had 3 hours of sleep, the second 5 hours. Best of luck, Winter Age: 51, dx at 5010/2011 PSA 47.83, T 270Biopsy: 11/2011: 8 of 14 cores, right side, 80-90%. CT Scan: lymph neg, soft tissue mass posterior to prostate HT: 12/2011, start clinical trail neo-adjuvant Lupron/Abiraterone/Prednisone1/2012 PSA 1.65, T 2 : 2/2012 PSA 0.11, T 3 : 3/2012 PSA 0.05, T 3 Bud, Winter is correct that the effects should decrease in time. I would like to recommend removing coffee, but that is impossible for me - hey, you have to have some sort of vice left after all this right? The only things that seem to help are exercise everyday, and cut out sugar. When I get super hungry, I try and fill up on boring stuff like a huge bowl of broccoli - no butter, just some nice olive oil.
Abiraterone acetate in combination with prednisone or prednisolone at a low. In the phase I and II trials, abiraterone acetate was administered without any. Apr 14, 2016. I have heard a few prostate cancer patients comment that they are worried about taking Zytiga abiraterone because they are concerned about.