* Januvia plus Actos superior to Actos alone * 60 pct of patients reach blood sugar goal vs 28 pct * Januvia and insulin top insulin alone By Bill Berkrot NEW YORK, June 6 (Reuters) - Merck & Co Inc’s () fast growing diabetes drug Januvia proved effective in helping patients lower blood sugar in combination with Takeda’s Actos, and when used along with insulin therapy, according to data from a pair of clinical trials. In a 497-patient, 24-week study, treatment with Januvia plus Actos as an initial therapy resulted in a 2.4 percent reduction in A1C level compared with a 1.5 percent reduction for patients taking the Takeda Pharmaceutical Co Ltd () drug alone, Merck said. The difference was considered to be statistically significant. A1C is a key measure of a person’s average blood glucose level over a two- to three-month period. The American Diabetes Association (ADA) guidelines call for A1C levels of 7 percent or less. Type 2 diabetes patients began the trial with A1C levels of 8 percent to 12 percent. Sixty percent of those who received the combination therapy achieved an A1C of less than 7 percent, compared with 28 percent of patients who only took Actos, known chemically as pioglitazone, according to data presented on Saturday at the annual ADA scientific meeting in New Orleans. What do a Swiss Army knife, Pantene Pro-V Full & Thick 2-in-1 Shampoo Conditioner, and Glucovance have in common? They're all combination products, designed to save you time, money, or both. Drug companies are introducing more combo medications -- two drugs in one pill -- to take advantage of patent expirations and competition from generics. Glucovance is a combination of glyburide and metformin, two medications that help people with type 2 control blood glucose. Don't Miss: 7-Day Diabetes Diet Dinner Plan Most combination pills deliver just two different types of medicine. Usually the two meds work together to treat one disease in different ways. Some pills contain two drugs to treat conditions that commonly occur together, such as high blood pressure and high cholesterol.
Sitagliptin is used with a proper diet and exercise program and possibly with other medications to control high blood sugar. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Sitagliptin is a diabetes drug that works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. Read the Medication Guide provided by your pharmacist before you start using sitagliptin and each time you get a refill. If you have any questions, ask your doctor or pharmacist. ’ (sitagliptin), when taken alone or in combination with metformin, provided significant blood sugar lowering over two years. “This analysis shows that, among patients with type 2 diabetes who completed two years of follow up, sitagliptin substantially lowered Hb A1c levels,” said John Amatruda, M. D., Senior Vice President and Franchise Head, Diabetes and Obesity, Merck Research Laboratories (MRL), Merck & Co., Inc. “Data demonstrating the efficacy and safety profiles of sitagliptin is an important consideration when physicians are treating patients who have chronic illnesses like diabetes.” Sitagliptin is a highly selective, once-daily DPP-4 inhibitor that enhances a natural body system called the incretin system, to help regulate blood sugar by increasing levels of active GLP-1 and GIP hormones; it inhibits DPP-4 over 24 hours. The fixed-dose combination of sitagliptin and metformin targets all three key defects of diabetes: insulin deficiency from pancreatic beta cells, insulin resistance, and overproduction of glucose by the liver. The fixed dose combination is not available in some EU countries, including the UK. Sitagliptin is the first approved medicine in the DPP-4 inhibitor class of oral treatments.
Sitagliptin (Januvia) is an incretin enhancer and the first medication from the gliptin class to be marketed. Incretin hormones are released from intestinal cells in response to carbohydrate- or fat-rich meals and stimulate pancreatic beta cells to release insulin, which stops hepatic glucose production. Sitagliptin prolongs the action of incretin hormones by prohibiting their degradation through inhibition of the dipeptidyl peptidase-4 enzyme. Sitagliptin is labeled as adjunct therapy to diet and exercise, metformin (Glucophage), or thiazolidinediones in adults with type 2 diabetes. Two large trials have assessed the effectiveness and safety of sitagliptin alone or in combination with metformin in adult patients with type 2 diabetes. Hypoglycemia rates in patients receiving sitagliptin were similar to those in patients receiving placebo or metformin alone, with no incidents of severe hypoglycemia13; however, it is unknown whether sitagliptin will increase hypoglycemic events when combined with sulfonyl-ureas or insulin. Hepatic insufficiency appears to have minimal effect on sitagliptin concentrations and requires no dosage adjustment. For many people, having diabetes means taking multiple medicines. These medicines may include diabetes pills, insulin, and other injectables. They can also include medicines for managing blood pressure, cholesterol, and other health issues. Taking all of this medicine means a greater chance for missed doses or mix-ups, as well as an increased number of prescriptions to remember to refill. It’s always important to discuss and review your medications with your health-care provider on a regular basis. When you do, ask your provider about combination diabetes drugs and if they might be an option for you. Benefits of combination drugs for diabetes If you have Type 2 diabetes, there’s a fairly high likelihood that at some point along the way, you’ll need medicine to help you manage your blood sugars. Certainly, many people can manage their diabetes with lifestyle measures — healthful eating, weight control, and regular physical activity.
When JANUVIA was used in combination with a sulfonylurea or with insulin. In the study of JANUVIA as add-on combination therapy with metformin and. Oct 3, 2017. Has anyone on here ever been on Januvia and Metformin at the same. We also have other members who take the combo, Janumet, so you.