I googled side effects of Tamoxifen today as been having terrible stiffness/aches all over, queasiness, kind of like bad flu symptoms. I've only been on Tamoxifen for 2 weeks after having surgery on 16 May to remove a lump and 2 lymph nodes (which were clear). I'm amazed reading that so many people are complaining of the same symptoms. I'm seeing my oncologist on Tuesday so have noted down questions to ask her as I'll probably forget when I get in there! Shoulders and neck pain like Sarfan, feeling tearful like Chriss. I was prescribed Tamoxifen rather than Letrozole because I take Alendronic Acid once a week for osteoporosis. and right down the answers as you get home and those answers are lost .. I must say though that the osteoporosis is manageable and I've been able to get on with things, going long walks etc. I think for arthritis, tamoxifen is the lesser of two evils ... But there's always someone who can relate to what your going through ... if you don't understand anything tell them to explain in a way we can understand ... After a 45 minute walk in the park the other day I was stuffed! you've heard what I said about the emotional side ... and like you my bones are very weak with lots of problems... and I think it's all settled down, except I do get tired and need a whole day in bed every week ... And yes this is a great place, coz no matter how good others are, they don't know how this journey effects us ... Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although articular tissues have long been considered unresponsive to estrogens or their deficiency, there is now increasing evidence that estrogens influence the activity of joint tissues through complex molecular pathways that act at multiple levels. Indeed, we are only just beginning to understand the effects of estrogen deficiency on articular tissues during OA development and progression, as well as on the association between OA and osteoporosis. Estrogen replacement therapy and current selective estrogen receptor modulators have mixed effectiveness in preserving and/or restoring joint tissue in OA. Thus, a better understanding of how estrogen acts on joints and other tissues in OA will aid the development of specific and safe estrogen ligands as novel therapeutic agents targeting the OA joint as a whole organ.]. Characteristic pathological changes in OA not only include joint cartilage degeneration but also subchondral bone thickening, osteophyte formation and synovial inflammation, all of which are associated with capsule laxitude and decreased muscle strength . The pathological changes that occur in OA are the result of the action of biomechanical forces coupled with multiple autocrine, paracrine and endocrine cellular events that lead to a breakdown of the normal balance in tissue turnover within the joint .
I am meeting my Oncologist tomorrow to discuss Hormone Therapy. I am 40 and ER and PR positive so I know I will be put on Tamoxifen. I was reading up about it last night and one of the side effects that is concerning me in particular is joint pain. I have arthritis in lumbar 5 and 6 of my spine, arthritis in my knees and also no cartlidge in my knees also. Also 5 weeks after AC x 4 cycles finished I developed a stiffness in my hips if sitting for a period of time. Suffice to say that my body feels like an auld crock at the moment and I am really concerned by mobility will be compromised even further with Tamoxifen as apparently 1 in 5 women experience this problem. I was unable to take Tamoxifen because the bone pain..just joint..so awful for me. After 3 months I chose to not to continue with the T. If any of your experience the joint pain, how did you handle it and did your Oncologist prescribed any medicine to help with this side effect? That being said..oncologist had never had any of his patients who had the pain that bad...fact his onc nurse was not even aware it was a side effect (this was 5 and a half years ago). Again, this is a question for the treating specialist, most likely a rheumatologist. When treating a disorder like ra, there are a variety of medications that have been effective; as with everything else in medicine, no one size fits all, and the right drug or combo for each must be assessed over time by a specialist. Read more See 1 more doctor answer "rheumatism" is an older term, not used much today. Most people are referring to pain and swelling in the joints when they use this term. People may mean something different when they use this term in contrast to when they refer But frequently unecessary in most of my RA patients. Combinations inclduing mtx with sulfasalazine, hydroxychlorquine, perhaps doxycycline, or Leflunomide should be tried before starting enbrel, (etanercept) unless you have overwhelming inflammatory disease. It should not be considered a first-line therapy, as drug companies want us to believe. Noenthless, Enbrel (etanercept) with mtx is better than either alone! Read more Rheumatoid arthritis can often be controlled with some of the newer medications including enbrel (etanercept). Other first line dmards like plaquenyl, methotrexate, leflunomide, and sulfasalazine work quite well. Many patients are saved from irreversible crippling of the joints. Read more See 2 more doctor answers Results are very good, particulary when used alone and better with methotrexate. I occasionally will give Humira (adalimumab) injections for several visits until other drugs kick in. Read more Humira is a tnfa antibody, and is similar to envbrel.
I was on Tamoxifen initially but couldn't tolerate it (extreme vaginal itching and discharge)so was switched to Arimidex about a year ago. I am now starting to experience discomfort on this, has any one else found this? I have a check-up this week, supposed to be 6 monthly but is 9 months since last one, I'm tempted to ask to come off Arimidex. I had only one little tumor that was invasive and estrogen receptive and I was reluctant to start Arimidex too... Am post-menopausal, sister died of BC at age 45 and maternal aunt, also, so may be genetic tendency. but my surgeon strongly suggested that it was better for me to take it for at least five years. Hoping that you will make the right decision after discussing it with your doctor. In the early breast cancer clinical trial, the most common side effects seen with ARIMIDEX include hot flashes, joint symptoms (including arthritis and arthralgia), weakness, mood changes, pain, back pain, sore throat, nausea and vomiting, rash, depression, high blood pressure, osteoporosis, fractures, swelling of arms/legs, insomnia, and headache. Patients taking ARIMIDEX were less likely than those taking tamoxifen to stop treatment because of side effects. I have been on Arimidex for 4 months and have a lot of pain in my knees, thighs, legs and feet. It actually feels like it moves around and throbs from muscles to bones and back.? I was on Tamoxefin before and had discomfort but no pain like this. Commonly reported side effects of tamoxifen include: amenorrhea, fluid retention, hot flash, nausea, vaginal discharge, vaginal hemorrhage, weight loss, and skin changes. Other side effects include: infection, sepsis, alopecia, constipation, cough, diarrhea, edema, increased serum aspartate aminotransferase, infrequent uterine bleeding, menstrual disease, ostealgia, vomiting, and weight gain. See below for a comprehensive list of adverse effects. Applies to tamoxifen: oral solution, oral tablet Along with its needed effects, tamoxifen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking tamoxifen: Some side effects of tamoxifen may occur that usually do not need medical attention. "UK Summary of Product Characteristics." O 0Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These side effects may go away during treatment as your body adjusts to the medicine.
Women on tamoxifen with arthritis symptoms Not long ago on this forum there was a posting and it was discovered that alot of us on tamoxifen were having trouble with arthritis. The big question is, is there a connection. May 16, 2017. Patients with cancer and concomitant rheumatoid arthritis pose special. and starts treatment with oral tamoxifen, returning to her full-time job.