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Viagra (sildenafil) and Levitra (vardenafil) are prescription medications used to treat erectile dysfunction and pulmonary arterial hypertension. Viagra was introduced by Pfizer Pharmaceuticals in March 1998 as a treatment for pulmonary arterial hypertension. The clinical trials revealed that the active ingredient — generically known as sildenafil citrate — also relaxed the muscle tissues in the penis, allowing for increased blood flow. Levitra, introduced in 2003 by Bayer Pharmaceuticals and marketed by Glaxo Smith Kline to treat erectile dysfunction, works similarly. In appearance, Viagra tablets are blue, rounded diamonds that are available in 25 mg, 50 mg, and 100 mg doses. Levitra has orange-colored tablets in 2.5 mg, 5 mg, 10 mg, and 20 mg doses. It is recommended that both medications be taken 30 to 60 minutes before sexual activity is intended. The most common medications used to treat erectile dysfunction (ED) are Viagra, Cialis, Sildenafil, and Levitra. They belong to a class of drugs called phosphodiesterase 5 inhibitors (PDE5 inhibitors), which will be explained below. An erection occurs when someone is stimulated by an erotic thought or sexual contact. That leads to a series of chemical reactions in the blood vessels of the penis that results in 6 times the blood flow getting trapped in the penis. An erection might last indefinitely if it weren’t for chemicals called phosphodiesterases. They work at reversing the process that keeps the penis erect. Usually there is a balance between the chemicals that cause an erection and those that would return the penis to being flaccid. They pull in opposite directions with one dominating over the other in a perfect sequence that lets a man have an erection as long as it is needed.
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