Amoxicillin usually starts working in 24-72 hours showing some improvements if the organism is susceptible to amoxicillin. If you are not noticing any improvent in 3-4 days you should notify your Dr or healthcare provider. I, personally and with my kids, have had no luck with amoxicillin for sinus infections. For one, amoxicillin works best on aerobic bacteria and sinus infections are usually caused by anaerobic bacterias. I dont know why Drs always want to prescribe amoxicillin as first line. I refuse it with my kids because it never works for them or if it does, as soon as they come off, the symptoms come right back. Augmentin is similar to amoxicillin but has a substance that breaks down the cell membrane of an anaerobic bacteria and allows the antibiotic to work better. If it has been a few days and there is no improvement, I would notify the Dr that it is not working. Good news: You might be able to shorten the time you take antibiotics. For decades, doctors have advised patients to take the drugs for at least a week or two, even if they feel better after just a few days. But a new study adds to a growing body of evidence suggesting that, in some cases, a shorter course of antibiotics works just as well—and is safer. In the study, published July 25 in JAMA Internal Medicine, Spanish researchers examined the use of antibiotics in 312 adults who had bacterial pneumonia severe enough to require hospitalization. The approximately half of patients randomized to “standard care” wound up taking antibiotics for an average of 10 days. In the other half, doctors stopped the drugs after 5 days as long as the patients didn’t have a fever and appeared to be on the mend. Ten days after the start of treatment, researchers found that patients who stopped the drugs early were faring just as well as those who kept taking them; after a month, the vast majority of both groups had recovered.
Jan 24, 2012. that is the sweet spot for most drugs long enough to definitely work. antibiotics such as amoxicillin are the weapons of choice for slowing or. Advice on amoxicillin dose, whether to take it with food and what to do if you. What is the dose of amoxicillin and how often should I take it?